The jihadist Islamic State group has faced major setbacks in Syria and Iraq over the past 15 months.

The latest was its loss on Thursday of its main supply route to Turkey.

Here are the key IS losses since January 2015 :

- Syria's Kobane recaptured -

After a series of victories, IS suffers its first serious setback on January 26, 2015 in Kobane, a Syrian Kurdish town near the border with Turkey known in Arabic as Ain al-Arab.

Kurdish forces backed by intense US-led air strikes capture the town after four months of fighting.

In June, Syrian Kurds also capture Tal Abyad, another town near the border that controls a supply route to Raqa, the IS de facto capital in northern Syria.

- Iraq retakes Saddam's hometown -

Iraqi troops, police and Shiite-dominated paramilitary forces retake Tikrit, the hometown of the late dictator Saddam Hussein, on March 31, 2015.

The operation, at that time the largest by Iraqi forces against IS, is aided by the fact that much of Tikrit's 200,000 residents had fled the city.

- Kurds cut key IS corridor -

On November 13, 2015, Iraqi Kurds backed by US-led coalition air strikes drive IS out of Sinjar, northwest of Baghdad, cutting one of the group's crucial supply lines between Iraq and Syria.

IS had seized Sinjar in August 2014 and carried out a brutal campaign against its Yazidi minority that included massacres, enslavement and rapes.

- Ramadi falls -

Iraqi troops retake a key district of the Sunni Arab city of Ramadi on December 8. Two weeks later, the troops backed by coalition air strikes reach the city's centre.

Ramadi is the capital of Anbar province, Iraq's largest which stretches from the borders with Syria, Jordan and Saudi Arabia to just west of Baghdad.

IS had seized Ramadi the previous May following an assault by dozens of suicide bombers driving explosives-rigged vehicles.

- Mosul and Palmyra -

On March 24, 2016 Iraqi forces oust jihadists from villages south of Mosul, IS's main hub in the country.

The army says the operation was the first phase of an offensive to recapture Nineveh province and its capital Mosul.

In Syria, regime forces backed by Russian warplanes and allied militia enter the IS-held ancient city of Palmyra retaking it a day later.

Known as the "Pearl of the Desert", Palmyra was overrun by IS in May 2015, since when the jihadists blew up UNESCO-listed temples and looted ancient relics.

- IS loses it main passage between Syria and Turkey -

On April 7, 2016 Syrian rebels seize control of the IS's main supply route to Turkey, the northeast of Al-Rai, following two days of clashes.

US strike in Syria kills several Al-Qaeda militants
Washington (AFP) April 6, 2016 - The United States has carried out another raid against Al-Qaeda militants in Syria, on the heels of a strike that killed the spokesman of the group's Syrian branch, the Pentagon said Wednesday.

"I can confirm that the US struck a vehicle killing several Al-Qaeda militants," said spokesman Matthew Allen. "The results of this strike are still being assessed."

The latest strike was carried out in northwestern Syria, according to a Defense department official who asked not to be named.

The Washington Post reported the latest raid was late Tuesday.

On Monday, the Pentagon said the US military conducted an air raid on an Al-Nusra meeting in northwest Syria the previous day.

Al-Qaeda's Syrian affiliate confirmed on Wednesday the death of its spokesman Abu Firas al-Suri in a US air strike.

US strikes on the Al-Nusra Front in Syria have not been very frequent with their raids overwhelmingly targeting the Islamic State group.

News of the strikes came as talks in Geneva aimed at ending the conflict loomed on April 11.

Syrian peace talks which fail to address the question of President Bashar al-Assad's fate are "doomed to failure", a spokesman for the main opposition grouping involved in negotiations said.

Riad Naasan Agha, of the Riyadh-based High Negotiations Committee, said that the talks which are set to resume must focus on the future of the Syrian leader.

"If negotiations did not address the fate of Assad, it would be a waste of time and doomed to failure," he said late Tuesday at a forum hosted by Al-Jazeera in Qatar.

The UN has said the upcoming round of talks will focus on plans for a political transition to lead Syria out of five years of brutal civil war.