Construction of the International Space Station scheduled to start later this year marks another milestone in space exploration. Research missions that once lasted only a few weeks, could routinely last many months, even years. But health effects of the space environment observed during short flights raise concerns about the safety and performance of astronauts during longer missions.

Because these detrimental effects could be intensified by extended

missions, NASA should support additional research into the

consequences of space flight on the biology and behavior of humans and

other organisms, says a new report from a committee of the National

Research Council.

The report provides a comprehensive review of the findings to date

from a wide range of life sciences research for space. It also

outlines the areas of research on humans and other organisms that NASA

should pursue if it is to successfully achieve such long-term goals as

operating the International Space Station, colonizing the moon, and

sending humans to Mars.

NASA should mount at least one more Spacelab-type mission to continue

the momentum of life sciences research in space and generate

additional data on the biological and psychological effects of space

travel, the committee said. It recommended specific research

priorities to ensure the safety and optimal performance of crews on

future extended missions.

NASA should concentrate on fully understanding how weightlessness

affects bone and muscle mass, blood pressure, sensory orientation, and

movement, in order to devise effective countermeasures, the committee

said. Losses in bone and muscle mass pose two of the greatest

obstacles to health and safety on long missions. Crew members on the

Russian space station Mir showed an average loss in bone mass density

of up to 1 percent a month in weight-bearing bones, the report notes.

Significant muscle atrophy has been recorded after only five days in

space. In-flight exercise programs proved helpful, but did not fully

prevent deterioration.

Changes in cardiovascular and pulmonary function have not yet been a

hindrance during space flight. However, two-thirds of the astronauts

tested after flights showed an impaired ability to maintain adequate

blood pressure. This condition could have more serious consequences

during docking and landing maneuvers involving rapid transitions

between gravitational force levels.

The agency should use the latest advances in molecular and cellular

biology to explore the underlying processes by which humans respond to

changes in gravity, the report says. Low gravity alters the body's

ability to sense direction and control motion, sometimes impairing

astronauts' ability to walk when they first return to Earth. This

condition could be exacerbated, the committee observed, and could

undermine the crew's abilities to operate the craft or disembark

rapidly in an emergency.

While space-based research will be crucial for advancing knowledge in

these areas, most research funding should be directed to ground-based

experiments — which are less costly to conduct — to answer

fundamental questions and frame hypotheses for testing in outer space.

For example, self-supporting colonies in outer space will require the

cultivation of plants in completely contained environments for food

and an oxygen source. So far this has not been successfully achieved

either on Earth or in space, the report notes.

The report emphasizes the need for more research on the impact of the

space environment's isolating and confining nature on astronauts'

behavior and performance. This is one of the least-studied effects of

space flight, yet the compatibility of crew members and their mental

well-being can greatly influence the ultimate success of a mission.

NASA also should improve its collection of data from astronauts to

answer fundamental questions about the effects of space travel on the

human body and mind. This process thus far has been arbitrary and

often hindered by astronauts' concerns about confidentiality. The

agency should revise its policies and practices to create a more

systematic approach to collecting and disseminating such information,

and encourage full cooperation and compliance from the astronauts.

In addition, NASA should encourage more timely publication of results

of experiments in peer-reviewed journals, and the agency should

provide the funding necessary to analyze and archive data so that it

is readily accessible to the scientific community.

The study was funded by NASA. The National Research Council is the

principal operating agency of the National Academy of Sciences and the

National Academy of Engineering. It is a private, non-profit

institution that provides science advice under a congressional

charter. A committee roster follows.

Copies of A Strategy for Research in Space Biology and Medicine In the

New Century are available from the National Academy Press for $49.00

(prepaid) plus shipping charges of $4.00 for the first copy and $.50

for each additional copy; tel. (202) 334-3313 or 1-800-624-6242.

Reporters may obtain a copy from the Office of News and Public

Information (contacts listed above).

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