Li will travel to Kyrgyzstan from next Tuesday to Friday where he will attend a meeting of Shanghai Cooperation Organization heads of government and conduct an official visit, foreign ministry spokesperson Mao Ning said.
China has renewed its push for massive infrastructure projects in Central Asia as it aims to fill a vacuum left in former Soviet states by Russia.
The region is a crucial link in China's trillion-dollar global infrastructure project, the Belt and Road Initiative.
Beijing says trade with Central Asia reached $70 billion last year.
In May, President Xi Jinping hosted Central Asian leaders at a summit in the northern Chinese city of Xi'an, urging them to "fully unleash" their potential in trade, economic and infrastructure cooperation.
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