"The US is threatening militarism. In my opinion, this threat is unwise," Khamenei said in a meeting with students. "Iran is capable of retaliating and will definitely inflict a blow."
The remarks came as local media in Iran reported that foreign minister Abbas Araghchi had received Trump's letter, which was delivered by senior United Arab Emirates official Anwar Gargash.
Khamenei, who noted he had not yet personally received the letter, said its invitation to talks was aimed at "deceiving the world's public opinion" by presenting the United States as ready to negotiate and Iran as unwilling.
"We sat down and negotiated for several years, this same person threw the finished, completed and signed agreement off the table and tore it up," he added, referring to Washington's withdrawal from a landmark 2015 nuclear deal during Trump's first term in office, which ended in 2021.
Since returning to the White House in January, Trump has called for a new nuclear deal with Tehran while reinstating his "maximum pressure" sanctions policy over concerns Iran is seeking to develop nuclear weapons.
Tehran denies the allegations.
Iran has officially ruled out direct talks as long as sanctions remain, and on Wednesday Khamenei said talks with the US "will not lift sanctions... and will make the sanctions knot tighter".
"Regarding nuclear weapons, it is said that we will not let Iran obtain nuclear weapons. If we wanted to make nuclear weapons, America could not stop us," Khamenei said.
"The fact that we do not have nuclear weapons and are not seeking nuclear weapons is because we ourselves do not want them."
Khamenei, who has final say in state matters, said Iran "was not seeking war, but if someone takes action, our response will be decisive and certain".
Iran weighs talks with US as Trump letter arrives
Tehran (AFP) Mar 12, 2025 -
With sanctions squeezing its economy, Iran is exploring the possibility of talks with the United States while resisting pressure to make major concessions.
Since returning to the White House in January, US President Donald Trump has called for a new nuclear deal with Tehran while reinstating his "maximum pressure" policy of sanctions.
Iran has officially ruled out direct talks as long as sanctions remain, with President Masoud Pezeshkian vowing on Tuesday that his country "will not bow in humiliation to anyone."
On Friday, Trump said he had sent a letter to Iran's supreme leader Ayatollah Ali Khamenei urging negotiations and warning of possible military action if Iran refused.
Local media reported that Iran's top diplomat Abbas Araghchi received Trump's letter, which was delivered by senior Emirati official Anwar Gargash.
On Wednesday, Khamenei, who said he had not yet personally received the letter, said the US threats were "unwise" and that negotiations "will not lift sanctions ... and will make the sanctions knot tighter."
He reiterated that Iran was "not seeking a nuclear weapon" and that the US invitation for talks was aimed at "deceiving the world's public opinion".
Observers say Tehran's stance remains focused on its atomic programme and not on wider issues.
"It seems that Iran is ready for limited negotiations -- in the sense that they will not extend beyond the nuclear issue," said foreign policy analyst Rahman Ghahremanpour.
Trump appeared to be seeking a "comprehensive agreement" covering Iran's nuclear programme, missile capabilities -- long criticised by Western governments -- and its "axis of resistance", a network of militant groups opposed to Israel.
On Sunday, Iran's mission to the United Nations said Tehran might consider talks only on "the potential militarisation" of its nuclear programme.
"Should the aim be the dismantlement of Iran's peaceful nuclear program... such negotiations will never take place," it said in a statement.
- 'New expectations' -
After Trump revealed that he had sent the letter, Khamenei slammed what he called "bullying" by some governments, saying negotiations with them served only for them to exert dominance.
"Negotiation is a path for them, a path to set new expectations," he said in a speech on Saturday.
"It is not just the nuclear issue that they are talking about now; they are setting new expectations that Iran will definitely not meet."
Khamenei, who has the final say on state matters, has warned that talks with the United States will not solve Iran's problems, citing past experience.
During his first term, which ended in January 2021, Trump reimposed heavy sanctions on Iran and pulled the United States out of the 2015 nuclear deal, calling it "the worst deal ever".
Tehran began rolling back its commitments to the agreement -- formally the Joint Comprehensive Plan of Action -- a year after Washington's withdrawal. Efforts to revive the deal have since faltered.
Millions of Iranians have struggled for years under crippling sanctions, which fuelled double-digit inflation and sent the rial plunging to 930,000 against the US dollar on the black market.
Ghahremanpour said leaders in both countries are using "political rhetoric" to show "their own voter base" that they are negotiating from a position of strength.
- 'No choice' -
Ali Bigdeli, an international relations expert, said Iran appears to be "preparing, either through Russian mediation or other countries such as Saudi Arabia, to accept nuclear negotiations."
Iranian diplomats have recently held nuclear talks with Britain, France and Germany, along with separate discussions with Russia.
On Wednesday, China announced it would host three-way nuclear talks with Russia and Iran later this week.
Iran's goal, according to Ghahremanpour, was to ensure that the United States "at least refrains from imposing new sanctions to prove its goodwill".
The UN atomic agency has warned that Iran has significantly increased its stockpile of highly enriched uranium to 60 percent purity -- close to the 90 percent needed for an atomic bomb.
Iran insists its nuclear programme is purely for peaceful purposes.
Bigdeli dismissed the likelihood of military action against Iran, warning it "could set the Middle East on fire".
But he believes Iran has "no choice but to negotiate" with the United States.
"Without talks with the West and sanctions relief, we cannot overcome these economic difficulties."
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